Recent and ongoing selection in the human genome

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Recent and ongoing selection in the human genome. / Nielsen, Rasmus; Hellmann, Ines; Hubisz, Melissa; Bustamante, Carlos; Clark, Andrew G.

In: Nature Reviews. Genetics, Vol. 8, No. 11, 2007, p. 857-68.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, R, Hellmann, I, Hubisz, M, Bustamante, C & Clark, AG 2007, 'Recent and ongoing selection in the human genome', Nature Reviews. Genetics, vol. 8, no. 11, pp. 857-68. https://doi.org/10.1038/nrg2187

APA

Nielsen, R., Hellmann, I., Hubisz, M., Bustamante, C., & Clark, A. G. (2007). Recent and ongoing selection in the human genome. Nature Reviews. Genetics, 8(11), 857-68. https://doi.org/10.1038/nrg2187

Vancouver

Nielsen R, Hellmann I, Hubisz M, Bustamante C, Clark AG. Recent and ongoing selection in the human genome. Nature Reviews. Genetics. 2007;8(11):857-68. https://doi.org/10.1038/nrg2187

Author

Nielsen, Rasmus ; Hellmann, Ines ; Hubisz, Melissa ; Bustamante, Carlos ; Clark, Andrew G. / Recent and ongoing selection in the human genome. In: Nature Reviews. Genetics. 2007 ; Vol. 8, No. 11. pp. 857-68.

Bibtex

@article{0634d800195311deb43e000ea68e967b,
title = "Recent and ongoing selection in the human genome",
abstract = "The recent availability of genome-scale genotyping data has led to the identification of regions of the human genome that seem to have been targeted by selection. These findings have increased our understanding of the evolutionary forces that affect the human genome, have augmented our knowledge of gene function and promise to increase our understanding of the genetic basis of disease. However, inferences of selection are challenged by several confounding factors, especially the complex demographic history of human populations, and concordance between studies is variable. Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings.",
author = "Rasmus Nielsen and Ines Hellmann and Melissa Hubisz and Carlos Bustamante and Clark, {Andrew G}",
note = "Keywords: Evolution, Molecular; Genetics, Population; Genome, Human; Humans; Selection (Genetics)",
year = "2007",
doi = "10.1038/nrg2187",
language = "English",
volume = "8",
pages = "857--68",
journal = "Nature Reviews. Genetics",
issn = "1471-0056",
publisher = "nature publishing group",
number = "11",

}

RIS

TY - JOUR

T1 - Recent and ongoing selection in the human genome

AU - Nielsen, Rasmus

AU - Hellmann, Ines

AU - Hubisz, Melissa

AU - Bustamante, Carlos

AU - Clark, Andrew G

N1 - Keywords: Evolution, Molecular; Genetics, Population; Genome, Human; Humans; Selection (Genetics)

PY - 2007

Y1 - 2007

N2 - The recent availability of genome-scale genotyping data has led to the identification of regions of the human genome that seem to have been targeted by selection. These findings have increased our understanding of the evolutionary forces that affect the human genome, have augmented our knowledge of gene function and promise to increase our understanding of the genetic basis of disease. However, inferences of selection are challenged by several confounding factors, especially the complex demographic history of human populations, and concordance between studies is variable. Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings.

AB - The recent availability of genome-scale genotyping data has led to the identification of regions of the human genome that seem to have been targeted by selection. These findings have increased our understanding of the evolutionary forces that affect the human genome, have augmented our knowledge of gene function and promise to increase our understanding of the genetic basis of disease. However, inferences of selection are challenged by several confounding factors, especially the complex demographic history of human populations, and concordance between studies is variable. Although such studies will always be associated with some uncertainty, steps can be taken to minimize the effects of confounding factors and improve our interpretation of their findings.

U2 - 10.1038/nrg2187

DO - 10.1038/nrg2187

M3 - Journal article

C2 - 17943193

VL - 8

SP - 857

EP - 868

JO - Nature Reviews. Genetics

JF - Nature Reviews. Genetics

SN - 1471-0056

IS - 11

ER -

ID: 11529433