Reconstructing ancient genomes and epigenomes

Research output: Contribution to journal › Review › Research › peer-review

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Reconstructing ancient genomes and epigenomes. / Orlando, Ludovic Antoine Alexandre; Gilbert, M. Thomas P.; Willerslev, Eske.

In: Nature Reviews. Genetics, Vol. 16, No. 7, 2015, p. 395-408.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Orlando, LAA, Gilbert, MTP & Willerslev, E 2015, 'Reconstructing ancient genomes and epigenomes', Nature Reviews. Genetics, vol. 16, no. 7, pp. 395-408. https://doi.org/10.1038/nrg3935

APA

Orlando, L. A. A., Gilbert, M. T. P., & Willerslev, E. (2015). Reconstructing ancient genomes and epigenomes. Nature Reviews. Genetics, 16(7), 395-408. https://doi.org/10.1038/nrg3935

Vancouver

Orlando LAA, Gilbert MTP, Willerslev E. Reconstructing ancient genomes and epigenomes. Nature Reviews. Genetics. 2015;16(7):395-408. https://doi.org/10.1038/nrg3935

Author

Orlando, Ludovic Antoine Alexandre ; Gilbert, M. Thomas P. ; Willerslev, Eske. / Reconstructing ancient genomes and epigenomes. In: Nature Reviews. Genetics. 2015 ; Vol. 16, No. 7. pp. 395-408.

Bibtex

@article{0d2d6a6a5ace46b9b570a4e5d6cbbdcb,
title = "Reconstructing ancient genomes and epigenomes",
abstract = "Research involving ancient DNA (aDNA) has experienced a true technological revolution in recent years through advances in the recovery of aDNA and, particularly, through applications of high-throughput sequencing. Formerly restricted to the analysis of only limited amounts of genetic information, aDNA studies have now progressed to whole-genome sequencing for an increasing number of ancient individuals and extinct species, as well as to epigenomic characterization. Such advances have enabled the sequencing of specimens of up to 1 million years old, which, owing to their extensive DNA damage and contamination, were previously not amenable to genetic analyses. In this Review, we discuss these varied technical challenges and solutions for sequencing ancient genomes and epigenomes.",
author = "Orlando, {Ludovic Antoine Alexandre} and Gilbert, {M. Thomas P.} and Eske Willerslev",
year = "2015",
doi = "10.1038/nrg3935",
language = "English",
volume = "16",
pages = "395--408",
journal = "Nature Reviews. Genetics",
issn = "1471-0056",
publisher = "nature publishing group",
number = "7",

}

RIS

TY - JOUR

T1 - Reconstructing ancient genomes and epigenomes

AU - Orlando, Ludovic Antoine Alexandre

AU - Gilbert, M. Thomas P.

AU - Willerslev, Eske

PY - 2015

Y1 - 2015

N2 - Research involving ancient DNA (aDNA) has experienced a true technological revolution in recent years through advances in the recovery of aDNA and, particularly, through applications of high-throughput sequencing. Formerly restricted to the analysis of only limited amounts of genetic information, aDNA studies have now progressed to whole-genome sequencing for an increasing number of ancient individuals and extinct species, as well as to epigenomic characterization. Such advances have enabled the sequencing of specimens of up to 1 million years old, which, owing to their extensive DNA damage and contamination, were previously not amenable to genetic analyses. In this Review, we discuss these varied technical challenges and solutions for sequencing ancient genomes and epigenomes.

AB - Research involving ancient DNA (aDNA) has experienced a true technological revolution in recent years through advances in the recovery of aDNA and, particularly, through applications of high-throughput sequencing. Formerly restricted to the analysis of only limited amounts of genetic information, aDNA studies have now progressed to whole-genome sequencing for an increasing number of ancient individuals and extinct species, as well as to epigenomic characterization. Such advances have enabled the sequencing of specimens of up to 1 million years old, which, owing to their extensive DNA damage and contamination, were previously not amenable to genetic analyses. In this Review, we discuss these varied technical challenges and solutions for sequencing ancient genomes and epigenomes.

U2 - 10.1038/nrg3935

DO - 10.1038/nrg3935

M3 - Review

AN - SCOPUS:84931566802

VL - 16

SP - 395

EP - 408

JO - Nature Reviews. Genetics

JF - Nature Reviews. Genetics

SN - 1471-0056

IS - 7

ER -

ID: 154748072