Sentinel surveillance and epidemiology of Clostridioides difficile in Denmark, 2016 to 2019

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Sentinel surveillance and epidemiology of Clostridioides difficile in Denmark, 2016 to 2019. / Persson, Søren; Nielsen, Hans Linde; Coia, John Eugenio; Engberg, Jørgen; Olesen, Bente Scharvik; Engsbro, Anne Line; Petersen, Andreas Munk; Holt, Hanne Marie; Lemming, Lars; Marmolin, Ea Sofie; Søndergaard, Turid Snekloth; Andersen, Leif Percival; Jensen, Mie Birgitte Frid; Wiuff, Camilla; Sørensen, Gitte; Nielsen, Sofie Holtsmark; Nielsen, Eva Møller.

In: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, Vol. 27, No. 49, 2200244, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Persson, S, Nielsen, HL, Coia, JE, Engberg, J, Olesen, BS, Engsbro, AL, Petersen, AM, Holt, HM, Lemming, L, Marmolin, ES, Søndergaard, TS, Andersen, LP, Jensen, MBF, Wiuff, C, Sørensen, G, Nielsen, SH & Nielsen, EM 2022, 'Sentinel surveillance and epidemiology of Clostridioides difficile in Denmark, 2016 to 2019', Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, vol. 27, no. 49, 2200244. https://doi.org/10.2807/1560-7917.ES.2022.27.49.2200244

APA

Persson, S., Nielsen, H. L., Coia, J. E., Engberg, J., Olesen, B. S., Engsbro, A. L., Petersen, A. M., Holt, H. M., Lemming, L., Marmolin, E. S., Søndergaard, T. S., Andersen, L. P., Jensen, M. B. F., Wiuff, C., Sørensen, G., Nielsen, S. H., & Nielsen, E. M. (2022). Sentinel surveillance and epidemiology of Clostridioides difficile in Denmark, 2016 to 2019. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 27(49), [2200244]. https://doi.org/10.2807/1560-7917.ES.2022.27.49.2200244

Vancouver

Persson S, Nielsen HL, Coia JE, Engberg J, Olesen BS, Engsbro AL et al. Sentinel surveillance and epidemiology of Clostridioides difficile in Denmark, 2016 to 2019. Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2022;27(49). 2200244. https://doi.org/10.2807/1560-7917.ES.2022.27.49.2200244

Author

Persson, Søren ; Nielsen, Hans Linde ; Coia, John Eugenio ; Engberg, Jørgen ; Olesen, Bente Scharvik ; Engsbro, Anne Line ; Petersen, Andreas Munk ; Holt, Hanne Marie ; Lemming, Lars ; Marmolin, Ea Sofie ; Søndergaard, Turid Snekloth ; Andersen, Leif Percival ; Jensen, Mie Birgitte Frid ; Wiuff, Camilla ; Sørensen, Gitte ; Nielsen, Sofie Holtsmark ; Nielsen, Eva Møller. / Sentinel surveillance and epidemiology of Clostridioides difficile in Denmark, 2016 to 2019. In: Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin. 2022 ; Vol. 27, No. 49.

Bibtex

@article{9c48c80d065c4e6286c211315698cd61,
title = "Sentinel surveillance and epidemiology of Clostridioides difficile in Denmark, 2016 to 2019",
abstract = "BackgroundSince 2008, Danish national surveillance of Clostridioides difficile has focused on binary toxin-positive strains in order to monitor epidemic types such as PCR ribotype (RT) 027 and 078. Additional surveillance is needed to provide a more unbiased representation of all strains from the clinical reservoir.AimSetting up a new sentinel surveillance scheme for an improved understanding of type distribution relative to time, geography and epidemiology, here presenting data from 2016 to 2019.MethodsFor 2─4 weeks in spring and autumn each year between 2016 and 2019, all 10 Danish Departments of Clinical Microbiology collected faecal samples containing toxigenic C. difficile. Isolates were typed at the national reference laboratory at Statens Serum Institut. The typing method in 2016-17 used tandem-repeat-sequence typing, while the typing method in 2018-19 was whole genome sequencing.ResultsDuring the study period, the sentinel surveillance scheme included ca 14-15% of all Danish cases of C. difficile infections. Binary toxin-negative strains accounted for 75% and 16 of the 20 most prevalent types. The most common sequence types (ST) were ST2/13 (RT014/020) (19.5%), ST1 (RT027) (10.8%), ST11 (RT078) (6.7%), ST8 (RT002) (6.6%) and ST6 (RT005/117) (5.1%). The data also highlighted geographical differences, mostly related to ST1 and temporal decline of ST1 (p = 0.0008) and the increase of ST103 (p = 0.002), ST17 (p = 0.004) and ST37 (p = 0.003), the latter three binary toxin-negative.ConclusionSentinel surveillance allowed nationwide monitoring of geographical differences and temporal changes in C. difficile infections in Denmark, including emerging types, regardless of binary toxin status. ",
keywords = "Humans, Clostridioides difficile/genetics, Clostridioides/genetics, Sentinel Surveillance, Clostridium Infections/epidemiology, Ribotyping/methods, Denmark/epidemiology",
author = "S{\o}ren Persson and Nielsen, {Hans Linde} and Coia, {John Eugenio} and J{\o}rgen Engberg and Olesen, {Bente Scharvik} and Engsbro, {Anne Line} and Petersen, {Andreas Munk} and Holt, {Hanne Marie} and Lars Lemming and Marmolin, {Ea Sofie} and S{\o}ndergaard, {Turid Snekloth} and Andersen, {Leif Percival} and Jensen, {Mie Birgitte Frid} and Camilla Wiuff and Gitte S{\o}rensen and Nielsen, {Sofie Holtsmark} and Nielsen, {Eva M{\o}ller}",
year = "2022",
doi = "10.2807/1560-7917.ES.2022.27.49.2200244",
language = "English",
volume = "27",
journal = "Eurosurveillance",
issn = "1025-496X",
publisher = "Centre Europeen pour la Surveillance Epidemiologique du SIDA",
number = "49",

}

RIS

TY - JOUR

T1 - Sentinel surveillance and epidemiology of Clostridioides difficile in Denmark, 2016 to 2019

AU - Persson, Søren

AU - Nielsen, Hans Linde

AU - Coia, John Eugenio

AU - Engberg, Jørgen

AU - Olesen, Bente Scharvik

AU - Engsbro, Anne Line

AU - Petersen, Andreas Munk

AU - Holt, Hanne Marie

AU - Lemming, Lars

AU - Marmolin, Ea Sofie

AU - Søndergaard, Turid Snekloth

AU - Andersen, Leif Percival

AU - Jensen, Mie Birgitte Frid

AU - Wiuff, Camilla

AU - Sørensen, Gitte

AU - Nielsen, Sofie Holtsmark

AU - Nielsen, Eva Møller

PY - 2022

Y1 - 2022

N2 - BackgroundSince 2008, Danish national surveillance of Clostridioides difficile has focused on binary toxin-positive strains in order to monitor epidemic types such as PCR ribotype (RT) 027 and 078. Additional surveillance is needed to provide a more unbiased representation of all strains from the clinical reservoir.AimSetting up a new sentinel surveillance scheme for an improved understanding of type distribution relative to time, geography and epidemiology, here presenting data from 2016 to 2019.MethodsFor 2─4 weeks in spring and autumn each year between 2016 and 2019, all 10 Danish Departments of Clinical Microbiology collected faecal samples containing toxigenic C. difficile. Isolates were typed at the national reference laboratory at Statens Serum Institut. The typing method in 2016-17 used tandem-repeat-sequence typing, while the typing method in 2018-19 was whole genome sequencing.ResultsDuring the study period, the sentinel surveillance scheme included ca 14-15% of all Danish cases of C. difficile infections. Binary toxin-negative strains accounted for 75% and 16 of the 20 most prevalent types. The most common sequence types (ST) were ST2/13 (RT014/020) (19.5%), ST1 (RT027) (10.8%), ST11 (RT078) (6.7%), ST8 (RT002) (6.6%) and ST6 (RT005/117) (5.1%). The data also highlighted geographical differences, mostly related to ST1 and temporal decline of ST1 (p = 0.0008) and the increase of ST103 (p = 0.002), ST17 (p = 0.004) and ST37 (p = 0.003), the latter three binary toxin-negative.ConclusionSentinel surveillance allowed nationwide monitoring of geographical differences and temporal changes in C. difficile infections in Denmark, including emerging types, regardless of binary toxin status.

AB - BackgroundSince 2008, Danish national surveillance of Clostridioides difficile has focused on binary toxin-positive strains in order to monitor epidemic types such as PCR ribotype (RT) 027 and 078. Additional surveillance is needed to provide a more unbiased representation of all strains from the clinical reservoir.AimSetting up a new sentinel surveillance scheme for an improved understanding of type distribution relative to time, geography and epidemiology, here presenting data from 2016 to 2019.MethodsFor 2─4 weeks in spring and autumn each year between 2016 and 2019, all 10 Danish Departments of Clinical Microbiology collected faecal samples containing toxigenic C. difficile. Isolates were typed at the national reference laboratory at Statens Serum Institut. The typing method in 2016-17 used tandem-repeat-sequence typing, while the typing method in 2018-19 was whole genome sequencing.ResultsDuring the study period, the sentinel surveillance scheme included ca 14-15% of all Danish cases of C. difficile infections. Binary toxin-negative strains accounted for 75% and 16 of the 20 most prevalent types. The most common sequence types (ST) were ST2/13 (RT014/020) (19.5%), ST1 (RT027) (10.8%), ST11 (RT078) (6.7%), ST8 (RT002) (6.6%) and ST6 (RT005/117) (5.1%). The data also highlighted geographical differences, mostly related to ST1 and temporal decline of ST1 (p = 0.0008) and the increase of ST103 (p = 0.002), ST17 (p = 0.004) and ST37 (p = 0.003), the latter three binary toxin-negative.ConclusionSentinel surveillance allowed nationwide monitoring of geographical differences and temporal changes in C. difficile infections in Denmark, including emerging types, regardless of binary toxin status.

KW - Humans

KW - Clostridioides difficile/genetics

KW - Clostridioides/genetics

KW - Sentinel Surveillance

KW - Clostridium Infections/epidemiology

KW - Ribotyping/methods

KW - Denmark/epidemiology

U2 - 10.2807/1560-7917.ES.2022.27.49.2200244

DO - 10.2807/1560-7917.ES.2022.27.49.2200244

M3 - Journal article

C2 - 36695439

VL - 27

JO - Eurosurveillance

JF - Eurosurveillance

SN - 1025-496X

IS - 49

M1 - 2200244

ER -

ID: 334021993