Single-Locus Tests of Microsatellite Evolution: Multi-Step Mutations and Constraints on Allele Size

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Standard

Single-Locus Tests of Microsatellite Evolution : Multi-Step Mutations and Constraints on Allele Size. / Nielsen, Rasmus; Palsbøll, Per J.

In: Molecular Phylogenetics and Evolution, Vol. 11, No. 3, 1999, p. 477-484.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nielsen, R & Palsbøll, PJ 1999, 'Single-Locus Tests of Microsatellite Evolution: Multi-Step Mutations and Constraints on Allele Size', Molecular Phylogenetics and Evolution, vol. 11, no. 3, pp. 477-484. https://doi.org/10.1006/mpev.1998.0597

APA

Nielsen, R., & Palsbøll, P. J. (1999). Single-Locus Tests of Microsatellite Evolution: Multi-Step Mutations and Constraints on Allele Size. Molecular Phylogenetics and Evolution, 11(3), 477-484. https://doi.org/10.1006/mpev.1998.0597

Vancouver

Nielsen R, Palsbøll PJ. Single-Locus Tests of Microsatellite Evolution: Multi-Step Mutations and Constraints on Allele Size. Molecular Phylogenetics and Evolution. 1999;11(3):477-484. https://doi.org/10.1006/mpev.1998.0597

Author

Nielsen, Rasmus ; Palsbøll, Per J. / Single-Locus Tests of Microsatellite Evolution : Multi-Step Mutations and Constraints on Allele Size. In: Molecular Phylogenetics and Evolution. 1999 ; Vol. 11, No. 3. pp. 477-484.

Bibtex

@article{73db34d629f94f839919390e3b8e6610,
title = "Single-Locus Tests of Microsatellite Evolution: Multi-Step Mutations and Constraints on Allele Size",
abstract = "We evaluate some common simulation procedures as well as a recently developed likelihood method used for testing hypotheses regarding microsatellite evolution. Results from simulated data revealed that the tests for the detection of multi-step mutations in general have some power, whereas tests for the presence of constraints on the repeat number have only very limited power. The tests were applied to population data obtained from nine different baleen whale populations. High agreement was found between results obtained using the simulation-based approach and results obtained using a likelihood ratio test. In four of the nine population samples the tests rejected the one-step mutation model. In two instances the significant deviation was due to excess of heterozygosity and in two instances to a reduced level of heterozygosity relative to the expectations under the stepwise mutation model. The former significant deviation was consistent with occasional multi-step mutations, whereas the latter may indicate the presence of constraints on the number of repeats.",
keywords = "constraints on allele size, Microsatellite evolution, multi-step mutations, stepwise mutation model",
author = "Rasmus Nielsen and Palsb{\o}ll, {Per J.}",
year = "1999",
doi = "10.1006/mpev.1998.0597",
language = "English",
volume = "11",
pages = "477--484",
journal = "Molecular Phylogenetics and Evolution",
issn = "1055-7903",
publisher = "Academic Press",
number = "3",

}

RIS

TY - JOUR

T1 - Single-Locus Tests of Microsatellite Evolution

T2 - Multi-Step Mutations and Constraints on Allele Size

AU - Nielsen, Rasmus

AU - Palsbøll, Per J.

PY - 1999

Y1 - 1999

N2 - We evaluate some common simulation procedures as well as a recently developed likelihood method used for testing hypotheses regarding microsatellite evolution. Results from simulated data revealed that the tests for the detection of multi-step mutations in general have some power, whereas tests for the presence of constraints on the repeat number have only very limited power. The tests were applied to population data obtained from nine different baleen whale populations. High agreement was found between results obtained using the simulation-based approach and results obtained using a likelihood ratio test. In four of the nine population samples the tests rejected the one-step mutation model. In two instances the significant deviation was due to excess of heterozygosity and in two instances to a reduced level of heterozygosity relative to the expectations under the stepwise mutation model. The former significant deviation was consistent with occasional multi-step mutations, whereas the latter may indicate the presence of constraints on the number of repeats.

AB - We evaluate some common simulation procedures as well as a recently developed likelihood method used for testing hypotheses regarding microsatellite evolution. Results from simulated data revealed that the tests for the detection of multi-step mutations in general have some power, whereas tests for the presence of constraints on the repeat number have only very limited power. The tests were applied to population data obtained from nine different baleen whale populations. High agreement was found between results obtained using the simulation-based approach and results obtained using a likelihood ratio test. In four of the nine population samples the tests rejected the one-step mutation model. In two instances the significant deviation was due to excess of heterozygosity and in two instances to a reduced level of heterozygosity relative to the expectations under the stepwise mutation model. The former significant deviation was consistent with occasional multi-step mutations, whereas the latter may indicate the presence of constraints on the number of repeats.

KW - constraints on allele size

KW - Microsatellite evolution

KW - multi-step mutations

KW - stepwise mutation model

U2 - 10.1006/mpev.1998.0597

DO - 10.1006/mpev.1998.0597

M3 - Journal article

C2 - 10196086

AN - SCOPUS:0033111624

VL - 11

SP - 477

EP - 484

JO - Molecular Phylogenetics and Evolution

JF - Molecular Phylogenetics and Evolution

SN - 1055-7903

IS - 3

ER -

ID: 222645409