The evolution of gene expression levels in mammalian organs

Research output: Contribution to journal › Journal article › Research › peer-review

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The evolution of gene expression levels in mammalian organs. / Brawand, David; Soumillon, Magali; Necsulea, Anamaria; Julien, Philippe; Csardi, Gabor; Harrigan, Patrick; Weier, Manuela; Liechti, Angelica; Aximu-Petri, Ayinuer; Kircher, Martin; Albert, Frank W.; Zeller, Ulrich; Khaitovich, Philipp; Gruetzner, Frank; Bergmann, Sven; Nielsen, Rasmus; Paeaebo, Svante; Kaessmann, Henrik.

In: Nature, Vol. 478, No. 7369, 20.10.2011, p. 343-348.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Brawand, D, Soumillon, M, Necsulea, A, Julien, P, Csardi, G, Harrigan, P, Weier, M, Liechti, A, Aximu-Petri, A, Kircher, M, Albert, FW, Zeller, U, Khaitovich, P, Gruetzner, F, Bergmann, S, Nielsen, R, Paeaebo, S & Kaessmann, H 2011, 'The evolution of gene expression levels in mammalian organs', Nature, vol. 478, no. 7369, pp. 343-348. https://doi.org/10.1038/nature10532

APA

Brawand, D., Soumillon, M., Necsulea, A., Julien, P., Csardi, G., Harrigan, P., Weier, M., Liechti, A., Aximu-Petri, A., Kircher, M., Albert, F. W., Zeller, U., Khaitovich, P., Gruetzner, F., Bergmann, S., Nielsen, R., Paeaebo, S., & Kaessmann, H. (2011). The evolution of gene expression levels in mammalian organs. Nature, 478(7369), 343-348. https://doi.org/10.1038/nature10532

Vancouver

Brawand D, Soumillon M, Necsulea A, Julien P, Csardi G, Harrigan P et al. The evolution of gene expression levels in mammalian organs. Nature. 2011 Oct 20;478(7369):343-348. https://doi.org/10.1038/nature10532

Author

Brawand, David ; Soumillon, Magali ; Necsulea, Anamaria ; Julien, Philippe ; Csardi, Gabor ; Harrigan, Patrick ; Weier, Manuela ; Liechti, Angelica ; Aximu-Petri, Ayinuer ; Kircher, Martin ; Albert, Frank W. ; Zeller, Ulrich ; Khaitovich, Philipp ; Gruetzner, Frank ; Bergmann, Sven ; Nielsen, Rasmus ; Paeaebo, Svante ; Kaessmann, Henrik. / The evolution of gene expression levels in mammalian organs. In: Nature. 2011 ; Vol. 478, No. 7369. pp. 343-348.

Bibtex

@article{2d95c275b03147ea981f812da23031e5,
title = "The evolution of gene expression levels in mammalian organs",
abstract = "Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. We show that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation. Although gene expression evolution in mammals was strongly shaped by purifying selection, we identify numerous potentially selectively driven expression switches, which occurred at different rates across lineages and tissues and which probably contributed to the specific organ biology of various mammals.",
author = "David Brawand and Magali Soumillon and Anamaria Necsulea and Philippe Julien and Gabor Csardi and Patrick Harrigan and Manuela Weier and Angelica Liechti and Ayinuer Aximu-Petri and Martin Kircher and Albert, {Frank W.} and Ulrich Zeller and Philipp Khaitovich and Frank Gruetzner and Sven Bergmann and Rasmus Nielsen and Svante Paeaebo and Henrik Kaessmann",
year = "2011",
month = oct,
day = "20",
doi = "10.1038/nature10532",
language = "English",
volume = "478",
pages = "343--348",
journal = "Nature",
issn = "0028-0836",
publisher = "nature publishing group",
number = "7369",

}

RIS

TY - JOUR

T1 - The evolution of gene expression levels in mammalian organs

AU - Brawand, David

AU - Soumillon, Magali

AU - Necsulea, Anamaria

AU - Julien, Philippe

AU - Csardi, Gabor

AU - Harrigan, Patrick

AU - Weier, Manuela

AU - Liechti, Angelica

AU - Aximu-Petri, Ayinuer

AU - Kircher, Martin

AU - Albert, Frank W.

AU - Zeller, Ulrich

AU - Khaitovich, Philipp

AU - Gruetzner, Frank

AU - Bergmann, Sven

AU - Nielsen, Rasmus

AU - Paeaebo, Svante

AU - Kaessmann, Henrik

PY - 2011/10/20

Y1 - 2011/10/20

N2 - Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. We show that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation. Although gene expression evolution in mammals was strongly shaped by purifying selection, we identify numerous potentially selectively driven expression switches, which occurred at different rates across lineages and tissues and which probably contributed to the specific organ biology of various mammals.

AB - Changes in gene expression are thought to underlie many of the phenotypic differences between species. However, large-scale analyses of gene expression evolution were until recently prevented by technological limitations. Here we report the sequencing of polyadenylated RNA from six organs across ten species that represent all major mammalian lineages (placentals, marsupials and monotremes) and birds (the evolutionary outgroup), with the goal of understanding the dynamics of mammalian transcriptome evolution. We show that the rate of gene expression evolution varies among organs, lineages and chromosomes, owing to differences in selective pressures: transcriptome change was slow in nervous tissues and rapid in testes, slower in rodents than in apes and monotremes, and rapid for the X chromosome right after its formation. Although gene expression evolution in mammals was strongly shaped by purifying selection, we identify numerous potentially selectively driven expression switches, which occurred at different rates across lineages and tissues and which probably contributed to the specific organ biology of various mammals.

U2 - 10.1038/nature10532

DO - 10.1038/nature10532

M3 - Journal article

C2 - 22012392

VL - 478

SP - 343

EP - 348

JO - Nature

JF - Nature

SN - 0028-0836

IS - 7369

ER -

ID: 49697350