The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens)
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The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens). / Zhang, Wanchang; Wang, Hongru; Brandt, Débora Y. C.; Hu, Beijuan; Sheng, Junqing; Wang, Mengnan; Luo, Haijiang; Li, Yahui; Guo, Shujie; Sheng, Bin; Zeng, Qi; Peng, Kou; Zhao, Daxian; Jian, Shaoqing; Wu, Di; Wang, Junhua; Zhao, Guang; Ren, Jun; Shi, Wentian; van Esch, Joep H. M.; Klingunga, Sirawut; Nielsen, Rasmus; Hong, Yijiang.
In: Science Advances, Vol. 8, No. 38, eabm4955, 2022.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The genetic architecture of phenotypic diversity in the Betta fish (Betta splendens)
AU - Zhang, Wanchang
AU - Wang, Hongru
AU - Brandt, Débora Y. C.
AU - Hu, Beijuan
AU - Sheng, Junqing
AU - Wang, Mengnan
AU - Luo, Haijiang
AU - Li, Yahui
AU - Guo, Shujie
AU - Sheng, Bin
AU - Zeng, Qi
AU - Peng, Kou
AU - Zhao, Daxian
AU - Jian, Shaoqing
AU - Wu, Di
AU - Wang, Junhua
AU - Zhao, Guang
AU - Ren, Jun
AU - Shi, Wentian
AU - van Esch, Joep H. M.
AU - Klingunga, Sirawut
AU - Nielsen, Rasmus
AU - Hong, Yijiang
N1 - Publisher Copyright: © 2022 The Authors.
PY - 2022
Y1 - 2022
N2 - The Betta fish displays a remarkable variety of phenotypes selected during domestication. However, the genetic basis underlying these traits remains largely unexplored. Here, we report a high-quality genome assembly and resequencing of 727 individuals representing diverse morphotypes of the Betta fish. We show that current breeds have a complex domestication history with extensive introgression with wild species. Using a genome-wide association study, we identify the genetic basis of multiple traits, including coloration patterns, the "Dumbo"phenotype with pectoral fin outgrowth, extraordinary enlargement of body size that we map to a major locus on chromosome 8, the sex determination locus that we map to dmrt1, and the long-fin phenotype that maps to the locus containing kcnj15. We also identify a polygenic signal related to aggression, involving multiple neural system-related genes such as esyt2, apbb2, and pank2. Our study provides a resource for developing the Betta fish as a genetic model for morphological and behavioral research in vertebrates.
AB - The Betta fish displays a remarkable variety of phenotypes selected during domestication. However, the genetic basis underlying these traits remains largely unexplored. Here, we report a high-quality genome assembly and resequencing of 727 individuals representing diverse morphotypes of the Betta fish. We show that current breeds have a complex domestication history with extensive introgression with wild species. Using a genome-wide association study, we identify the genetic basis of multiple traits, including coloration patterns, the "Dumbo"phenotype with pectoral fin outgrowth, extraordinary enlargement of body size that we map to a major locus on chromosome 8, the sex determination locus that we map to dmrt1, and the long-fin phenotype that maps to the locus containing kcnj15. We also identify a polygenic signal related to aggression, involving multiple neural system-related genes such as esyt2, apbb2, and pank2. Our study provides a resource for developing the Betta fish as a genetic model for morphological and behavioral research in vertebrates.
U2 - 10.1126/sciadv.abm4955
DO - 10.1126/sciadv.abm4955
M3 - Journal article
C2 - 36129976
AN - SCOPUS:85134822542
VL - 8
JO - Science advances
JF - Science advances
SN - 2375-2548
IS - 38
M1 - eabm4955
ER -
ID: 327387899