Standard
Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats. / Ballantyne, Kaye N; Ralf, Arwin; Aboukhalid, Rachid; Achakzai, Niaz M; Anjos, Maria J; Ayub, Qasim; Balažic, Jože; Ballantyne, Jack; Ballard, David J; Berger, Burkhard; Bobillo, Cecilia; Bouabdellah, Mehdi; Burri, Helen; Capal, Tomas; Caratti, Stefano; Cárdenas, Jorge; Cartault, François; Carvalho, Elizeu F; Carvalho, Monica; Cheng, Baowen; Coble, Michael D; Comas, David; Corach, Daniel; D'Amato, Maria E; Davison, Sean; de Knijff, Peter; De Ungria, Maria Corazon A; Decorte, Ronny; Dobosz, Tadeusz; Dupuy, Berit M; Elmrghni, Samir; Gliwiński, Mateusz; Gomes, Sara C; Grol, Laurens; Haas, Cordula; Hanson, Erin; Henke, Jürgen; Henke, Lotte; Herrera-Rodríguez, Fabiola; Hill, Carolyn R; Holmlund, Gunilla; Honda, Katsuya; Immel, Uta-Dorothee; Inokuchi, Shota; Jobling, Mark A; Kaddura, Mahmoud; Kim, Jong S; Kim, Soon H; Kim, Wook; King, Turi E; Klausriegler, Eva; Kling, Daniel; Kovačević, Lejla; Kovatsi, Leda; Krajewski, Paweł; Kravchenko, Sergey; Larmuseau, Maarten H D; Lee, Eun Young; Lessig, Ruediger; Livshits, Ludmila A; Marjanović, Damir; Minarik, Marek; Mizuno, Natsuko; Moreira, Helena; Morling, Niels; Mukherjee, Meeta; Munier, Patrick; Nagaraju, Javaregowda; Neuhuber, Franz; Nie, Shengjie; Nilasitsataporn, Premlaphat; Nishi, Takeki; Oh, Hye H; Olofsson, Jill Katharina; Onofri, Valerio; Palo, Jukka U; Pamjav, Horolma; Parson, Walther; Petlach, Michal; Phillips, Christopher; Ploski, Rafal; Prasad, Samayamantri P R; Primorac, Dragan; Purnomo, Gludhug A; Purps, Josephine; Rangel-Villalobos, Hector; Rębała, Krzysztof; Rerkamnuaychoke, Budsaba; Gonzalez, Danel Rey; Robino, Carlo; Roewer, Lutz; Rosa, Alexandra; Sajantila, Antti; Sala, Andrea; Salvador, Jazelyn M; Sanz, Paula; Schmitt, Cornelia; Sharma, Anil K; Silva, Dayse A; Shin, Kyoung-Jin; Sijen, Titia; Sirker, Miriam; Siváková, Daniela; Skaro, Vedrana; Solano-Matamoros, Carlos; Souto, Luis; Stenzl, Vlastimil; Sudoyo, Herawati; Court, Denise Syndercombe; Tagliabracci, Adriano; Taylor, Duncan; Tillmar, Andreas; Tsybovsky, Iosif S; Tyler-Smith, Chris; van der Gaag, Kristiaan J; Vanek, Daniel; Völgyi, Antónia; Ward, Denise; Willemse, Patricia; Yap, Eric P H; Yong, Rita Y Y; Pajnič, Irena Zupanič; Kayser, Manfred.
In:
Human Mutation, Vol. 35, No. 8, 08.2014, p. 1021-32.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Ballantyne, KN, Ralf, A, Aboukhalid, R, Achakzai, NM, Anjos, MJ, Ayub, Q, Balažic, J, Ballantyne, J, Ballard, DJ, Berger, B, Bobillo, C, Bouabdellah, M, Burri, H, Capal, T, Caratti, S, Cárdenas, J, Cartault, F, Carvalho, EF, Carvalho, M, Cheng, B, Coble, MD, Comas, D, Corach, D, D'Amato, ME, Davison, S, de Knijff, P, De Ungria, MCA, Decorte, R, Dobosz, T, Dupuy, BM, Elmrghni, S, Gliwiński, M, Gomes, SC, Grol, L, Haas, C, Hanson, E, Henke, J, Henke, L, Herrera-Rodríguez, F, Hill, CR, Holmlund, G, Honda, K, Immel, U-D, Inokuchi, S, Jobling, MA, Kaddura, M, Kim, JS, Kim, SH, Kim, W, King, TE, Klausriegler, E, Kling, D, Kovačević, L, Kovatsi, L, Krajewski, P, Kravchenko, S, Larmuseau, MHD, Lee, EY, Lessig, R, Livshits, LA, Marjanović, D, Minarik, M, Mizuno, N, Moreira, H
, Morling, N, Mukherjee, M, Munier, P, Nagaraju, J, Neuhuber, F, Nie, S, Nilasitsataporn, P, Nishi, T, Oh, HH
, Olofsson, JK, Onofri, V, Palo, JU, Pamjav, H, Parson, W, Petlach, M, Phillips, C, Ploski, R, Prasad, SPR, Primorac, D, Purnomo, GA, Purps, J, Rangel-Villalobos, H, Rębała, K, Rerkamnuaychoke, B, Gonzalez, DR, Robino, C, Roewer, L, Rosa, A, Sajantila, A, Sala, A, Salvador, JM, Sanz, P, Schmitt, C, Sharma, AK, Silva, DA, Shin, K-J, Sijen, T, Sirker, M, Siváková, D, Skaro, V, Solano-Matamoros, C, Souto, L, Stenzl, V, Sudoyo, H, Court, DS, Tagliabracci, A, Taylor, D, Tillmar, A, Tsybovsky, IS, Tyler-Smith, C, van der Gaag, KJ, Vanek, D, Völgyi, A, Ward, D, Willemse, P, Yap, EPH, Yong, RYY, Pajnič, IZ & Kayser, M 2014, '
Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats',
Human Mutation, vol. 35, no. 8, pp. 1021-32.
https://doi.org/10.1002/humu.22599APA
Ballantyne, K. N., Ralf, A., Aboukhalid, R., Achakzai, N. M., Anjos, M. J., Ayub, Q., Balažic, J., Ballantyne, J., Ballard, D. J., Berger, B., Bobillo, C., Bouabdellah, M., Burri, H., Capal, T., Caratti, S., Cárdenas, J., Cartault, F., Carvalho, E. F., Carvalho, M., ... Kayser, M. (2014).
Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats.
Human Mutation,
35(8), 1021-32.
https://doi.org/10.1002/humu.22599Vancouver
Ballantyne KN, Ralf A, Aboukhalid R, Achakzai NM, Anjos MJ, Ayub Q et al.
Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats.
Human Mutation. 2014 Aug;35(8):1021-32.
https://doi.org/10.1002/humu.22599Author
Ballantyne, Kaye N ; Ralf, Arwin ; Aboukhalid, Rachid ; Achakzai, Niaz M ; Anjos, Maria J ; Ayub, Qasim ; Balažic, Jože ; Ballantyne, Jack ; Ballard, David J ; Berger, Burkhard ; Bobillo, Cecilia ; Bouabdellah, Mehdi ; Burri, Helen ; Capal, Tomas ; Caratti, Stefano ; Cárdenas, Jorge ; Cartault, François ; Carvalho, Elizeu F ; Carvalho, Monica ; Cheng, Baowen ; Coble, Michael D ; Comas, David ; Corach, Daniel ; D'Amato, Maria E ; Davison, Sean ; de Knijff, Peter ; De Ungria, Maria Corazon A ; Decorte, Ronny ; Dobosz, Tadeusz ; Dupuy, Berit M ; Elmrghni, Samir ; Gliwiński, Mateusz ; Gomes, Sara C ; Grol, Laurens ; Haas, Cordula ; Hanson, Erin ; Henke, Jürgen ; Henke, Lotte ; Herrera-Rodríguez, Fabiola ; Hill, Carolyn R ; Holmlund, Gunilla ; Honda, Katsuya ; Immel, Uta-Dorothee ; Inokuchi, Shota ; Jobling, Mark A ; Kaddura, Mahmoud ; Kim, Jong S ; Kim, Soon H ; Kim, Wook ; King, Turi E ; Klausriegler, Eva ; Kling, Daniel ; Kovačević, Lejla ; Kovatsi, Leda ; Krajewski, Paweł ; Kravchenko, Sergey ; Larmuseau, Maarten H D ; Lee, Eun Young ; Lessig, Ruediger ; Livshits, Ludmila A ; Marjanović, Damir ; Minarik, Marek ; Mizuno, Natsuko ; Moreira, Helena ; Morling, Niels ; Mukherjee, Meeta ; Munier, Patrick ; Nagaraju, Javaregowda ; Neuhuber, Franz ; Nie, Shengjie ; Nilasitsataporn, Premlaphat ; Nishi, Takeki ; Oh, Hye H ; Olofsson, Jill Katharina ; Onofri, Valerio ; Palo, Jukka U ; Pamjav, Horolma ; Parson, Walther ; Petlach, Michal ; Phillips, Christopher ; Ploski, Rafal ; Prasad, Samayamantri P R ; Primorac, Dragan ; Purnomo, Gludhug A ; Purps, Josephine ; Rangel-Villalobos, Hector ; Rębała, Krzysztof ; Rerkamnuaychoke, Budsaba ; Gonzalez, Danel Rey ; Robino, Carlo ; Roewer, Lutz ; Rosa, Alexandra ; Sajantila, Antti ; Sala, Andrea ; Salvador, Jazelyn M ; Sanz, Paula ; Schmitt, Cornelia ; Sharma, Anil K ; Silva, Dayse A ; Shin, Kyoung-Jin ; Sijen, Titia ; Sirker, Miriam ; Siváková, Daniela ; Skaro, Vedrana ; Solano-Matamoros, Carlos ; Souto, Luis ; Stenzl, Vlastimil ; Sudoyo, Herawati ; Court, Denise Syndercombe ; Tagliabracci, Adriano ; Taylor, Duncan ; Tillmar, Andreas ; Tsybovsky, Iosif S ; Tyler-Smith, Chris ; van der Gaag, Kristiaan J ; Vanek, Daniel ; Völgyi, Antónia ; Ward, Denise ; Willemse, Patricia ; Yap, Eric P H ; Yong, Rita Y Y ; Pajnič, Irena Zupanič ; Kayser, Manfred. / Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats. In: Human Mutation. 2014 ; Vol. 35, No. 8. pp. 1021-32.
Bibtex
@article{a292aad762d64542b43a7b575ae5ff8f,
title = "Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats",
abstract = "Relevant for various areas of human genetics, Y-chromosomal STRs (Y-STRs) are commonly used for testing close paternal relationships amongst individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly-mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99919-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% non-unique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). AMOVA revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 fathers/son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database. This article is protected by copyright. All rights reserved.",
author = "Ballantyne, {Kaye N} and Arwin Ralf and Rachid Aboukhalid and Achakzai, {Niaz M} and Anjos, {Maria J} and Qasim Ayub and Jo{\v z}e Bala{\v z}ic and Jack Ballantyne and Ballard, {David J} and Burkhard Berger and Cecilia Bobillo and Mehdi Bouabdellah and Helen Burri and Tomas Capal and Stefano Caratti and Jorge C{\'a}rdenas and Fran{\c c}ois Cartault and Carvalho, {Elizeu F} and Monica Carvalho and Baowen Cheng and Coble, {Michael D} and David Comas and Daniel Corach and D'Amato, {Maria E} and Sean Davison and {de Knijff}, Peter and {De Ungria}, {Maria Corazon A} and Ronny Decorte and Tadeusz Dobosz and Dupuy, {Berit M} and Samir Elmrghni and Mateusz Gliwi{\'n}ski and Gomes, {Sara C} and Laurens Grol and Cordula Haas and Erin Hanson and J{\"u}rgen Henke and Lotte Henke and Fabiola Herrera-Rodr{\'i}guez and Hill, {Carolyn R} and Gunilla Holmlund and Katsuya Honda and Uta-Dorothee Immel and Shota Inokuchi and Jobling, {Mark A} and Mahmoud Kaddura and Kim, {Jong S} and Kim, {Soon H} and Wook Kim and King, {Turi E} and Eva Klausriegler and Daniel Kling and Lejla Kova{\v c}evi{\'c} and Leda Kovatsi and Pawe{\l} Krajewski and Sergey Kravchenko and Larmuseau, {Maarten H D} and Lee, {Eun Young} and Ruediger Lessig and Livshits, {Ludmila A} and Damir Marjanovi{\'c} and Marek Minarik and Natsuko Mizuno and Helena Moreira and Niels Morling and Meeta Mukherjee and Patrick Munier and Javaregowda Nagaraju and Franz Neuhuber and Shengjie Nie and Premlaphat Nilasitsataporn and Takeki Nishi and Oh, {Hye H} and Olofsson, {Jill Katharina} and Valerio Onofri and Palo, {Jukka U} and Horolma Pamjav and Walther Parson and Michal Petlach and Christopher Phillips and Rafal Ploski and Prasad, {Samayamantri P R} and Dragan Primorac and Purnomo, {Gludhug A} and Josephine Purps and Hector Rangel-Villalobos and Krzysztof R{\c e}ba{\l}a and Budsaba Rerkamnuaychoke and Gonzalez, {Danel Rey} and Carlo Robino and Lutz Roewer and Alexandra Rosa and Antti Sajantila and Andrea Sala and Salvador, {Jazelyn M} and Paula Sanz and Cornelia Schmitt and Sharma, {Anil K} and Silva, {Dayse A} and Kyoung-Jin Shin and Titia Sijen and Miriam Sirker and Daniela Siv{\'a}kov{\'a} and Vedrana Skaro and Carlos Solano-Matamoros and Luis Souto and Vlastimil Stenzl and Herawati Sudoyo and Court, {Denise Syndercombe} and Adriano Tagliabracci and Duncan Taylor and Andreas Tillmar and Tsybovsky, {Iosif S} and Chris Tyler-Smith and {van der Gaag}, {Kristiaan J} and Daniel Vanek and Ant{\'o}nia V{\"o}lgyi and Denise Ward and Patricia Willemse and Yap, {Eric P H} and Yong, {Rita Y Y} and Pajni{\v c}, {Irena Zupani{\v c}} and Manfred Kayser",
note = "This article is protected by copyright. All rights reserved.",
year = "2014",
month = aug,
doi = "10.1002/humu.22599",
language = "English",
volume = "35",
pages = "1021--32",
journal = "Human Mutation",
issn = "1059-7794",
publisher = "JohnWiley & Sons, Inc.",
number = "8",
}
RIS
TY - JOUR
T1 - Toward Male Individualization with Rapidly Mutating Y-Chromosomal Short Tandem Repeats
AU - Ballantyne, Kaye N
AU - Ralf, Arwin
AU - Aboukhalid, Rachid
AU - Achakzai, Niaz M
AU - Anjos, Maria J
AU - Ayub, Qasim
AU - Balažic, Jože
AU - Ballantyne, Jack
AU - Ballard, David J
AU - Berger, Burkhard
AU - Bobillo, Cecilia
AU - Bouabdellah, Mehdi
AU - Burri, Helen
AU - Capal, Tomas
AU - Caratti, Stefano
AU - Cárdenas, Jorge
AU - Cartault, François
AU - Carvalho, Elizeu F
AU - Carvalho, Monica
AU - Cheng, Baowen
AU - Coble, Michael D
AU - Comas, David
AU - Corach, Daniel
AU - D'Amato, Maria E
AU - Davison, Sean
AU - de Knijff, Peter
AU - De Ungria, Maria Corazon A
AU - Decorte, Ronny
AU - Dobosz, Tadeusz
AU - Dupuy, Berit M
AU - Elmrghni, Samir
AU - Gliwiński, Mateusz
AU - Gomes, Sara C
AU - Grol, Laurens
AU - Haas, Cordula
AU - Hanson, Erin
AU - Henke, Jürgen
AU - Henke, Lotte
AU - Herrera-Rodríguez, Fabiola
AU - Hill, Carolyn R
AU - Holmlund, Gunilla
AU - Honda, Katsuya
AU - Immel, Uta-Dorothee
AU - Inokuchi, Shota
AU - Jobling, Mark A
AU - Kaddura, Mahmoud
AU - Kim, Jong S
AU - Kim, Soon H
AU - Kim, Wook
AU - King, Turi E
AU - Klausriegler, Eva
AU - Kling, Daniel
AU - Kovačević, Lejla
AU - Kovatsi, Leda
AU - Krajewski, Paweł
AU - Kravchenko, Sergey
AU - Larmuseau, Maarten H D
AU - Lee, Eun Young
AU - Lessig, Ruediger
AU - Livshits, Ludmila A
AU - Marjanović, Damir
AU - Minarik, Marek
AU - Mizuno, Natsuko
AU - Moreira, Helena
AU - Morling, Niels
AU - Mukherjee, Meeta
AU - Munier, Patrick
AU - Nagaraju, Javaregowda
AU - Neuhuber, Franz
AU - Nie, Shengjie
AU - Nilasitsataporn, Premlaphat
AU - Nishi, Takeki
AU - Oh, Hye H
AU - Olofsson, Jill Katharina
AU - Onofri, Valerio
AU - Palo, Jukka U
AU - Pamjav, Horolma
AU - Parson, Walther
AU - Petlach, Michal
AU - Phillips, Christopher
AU - Ploski, Rafal
AU - Prasad, Samayamantri P R
AU - Primorac, Dragan
AU - Purnomo, Gludhug A
AU - Purps, Josephine
AU - Rangel-Villalobos, Hector
AU - Rębała, Krzysztof
AU - Rerkamnuaychoke, Budsaba
AU - Gonzalez, Danel Rey
AU - Robino, Carlo
AU - Roewer, Lutz
AU - Rosa, Alexandra
AU - Sajantila, Antti
AU - Sala, Andrea
AU - Salvador, Jazelyn M
AU - Sanz, Paula
AU - Schmitt, Cornelia
AU - Sharma, Anil K
AU - Silva, Dayse A
AU - Shin, Kyoung-Jin
AU - Sijen, Titia
AU - Sirker, Miriam
AU - Siváková, Daniela
AU - Skaro, Vedrana
AU - Solano-Matamoros, Carlos
AU - Souto, Luis
AU - Stenzl, Vlastimil
AU - Sudoyo, Herawati
AU - Court, Denise Syndercombe
AU - Tagliabracci, Adriano
AU - Taylor, Duncan
AU - Tillmar, Andreas
AU - Tsybovsky, Iosif S
AU - Tyler-Smith, Chris
AU - van der Gaag, Kristiaan J
AU - Vanek, Daniel
AU - Völgyi, Antónia
AU - Ward, Denise
AU - Willemse, Patricia
AU - Yap, Eric P H
AU - Yong, Rita Y Y
AU - Pajnič, Irena Zupanič
AU - Kayser, Manfred
N1 - This article is protected by copyright. All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - Relevant for various areas of human genetics, Y-chromosomal STRs (Y-STRs) are commonly used for testing close paternal relationships amongst individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly-mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99919-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% non-unique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). AMOVA revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 fathers/son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database. This article is protected by copyright. All rights reserved.
AB - Relevant for various areas of human genetics, Y-chromosomal STRs (Y-STRs) are commonly used for testing close paternal relationships amongst individuals and populations, and for male lineage identification. However, even the widely used 17-loci Yfiler set cannot resolve individuals and populations completely. Here, 52 centers generated quality-controlled data of 13 rapidly-mutating (RM) Y-STRs in 14,644 related and unrelated males from 111 worldwide populations. Strikingly, >99% of the 12,272 unrelated males were completely individualized. Haplotype diversity was extremely high (global: 0.9999985, regional: 0.99919-0.9999988). Haplotype sharing between populations was almost absent except for six (0.05%) of the 12,156 haplotypes. Haplotype sharing within populations was generally rare (0.8% non-unique haplotypes), significantly lower in urban (0.9%) than rural (2.1%) and highest in endogamous groups (14.3%). AMOVA revealed 99.98% of variation within populations, 0.018% among populations within groups, and 0.002% among groups. Of the 2,372 newly and 156 previously typed male relative pairs, 29% were differentiated including 27% of the 2,378 fathers/son pairs. Relative to Yfiler, haplotype diversity was increased in 86% of the populations tested and overall male relative differentiation was raised by 23.5%. Our study demonstrates the value of RM Y-STRs in identifying and separating unrelated and related males and provides a reference database. This article is protected by copyright. All rights reserved.
U2 - 10.1002/humu.22599
DO - 10.1002/humu.22599
M3 - Journal article
C2 - 24917567
VL - 35
SP - 1021
EP - 1032
JO - Human Mutation
JF - Human Mutation
SN - 1059-7794
IS - 8
ER -
