Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico. / García-Ortiz, Humberto; Barajas-Olmos, Francisco; Contreras-Cubas, Cecilia; Reynolds, Austin W.; Flores-Huacuja, Marlen; Snow, Meradeth; Ramos-Madrigal, Jazmín; Mendoza-Caamal, Elvia; Baca, Paulina; López-Escobar, Tomás A.; Bolnick, Deborah A.; Flores-Martínez, Silvia Esperanza; Ortiz-Lopez, Rocio; Kostic, Aleksandar David; Villafan-Bernal, José Rafael; Galaviz-Hernández, Carlos; Centeno-Cruz, Federico; García-Zapién, Alejandra Guadalupe; Monge-Cázares, Tulia; Lazalde-Ramos, Blanca Patricia; Loeza-Becerra, Francisco; Abrahantes-Pérez, María del Carmen; Rangel-Villalobos, Héctor; Sosa-Macías, Martha; Rojas-Martínez, Augusto; Martínez-Hernández, Angélica; Orozco, Lorena.

In: Genes, Vol. 13, No. 12, 2251, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

García-Ortiz, H, Barajas-Olmos, F, Contreras-Cubas, C, Reynolds, AW, Flores-Huacuja, M, Snow, M, Ramos-Madrigal, J, Mendoza-Caamal, E, Baca, P, López-Escobar, TA, Bolnick, DA, Flores-Martínez, SE, Ortiz-Lopez, R, Kostic, AD, Villafan-Bernal, JR, Galaviz-Hernández, C, Centeno-Cruz, F, García-Zapién, AG, Monge-Cázares, T, Lazalde-Ramos, BP, Loeza-Becerra, F, Abrahantes-Pérez, MDC, Rangel-Villalobos, H, Sosa-Macías, M, Rojas-Martínez, A, Martínez-Hernández, A & Orozco, L 2022, 'Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico', Genes, vol. 13, no. 12, 2251. https://doi.org/10.3390/genes13122251

APA

García-Ortiz, H., Barajas-Olmos, F., Contreras-Cubas, C., Reynolds, A. W., Flores-Huacuja, M., Snow, M., Ramos-Madrigal, J., Mendoza-Caamal, E., Baca, P., López-Escobar, T. A., Bolnick, D. A., Flores-Martínez, S. E., Ortiz-Lopez, R., Kostic, A. D., Villafan-Bernal, J. R., Galaviz-Hernández, C., Centeno-Cruz, F., García-Zapién, A. G., Monge-Cázares, T., ... Orozco, L. (2022). Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico. Genes, 13(12), [2251]. https://doi.org/10.3390/genes13122251

Vancouver

García-Ortiz H, Barajas-Olmos F, Contreras-Cubas C, Reynolds AW, Flores-Huacuja M, Snow M et al. Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico. Genes. 2022;13(12). 2251. https://doi.org/10.3390/genes13122251

Author

García-Ortiz, Humberto ; Barajas-Olmos, Francisco ; Contreras-Cubas, Cecilia ; Reynolds, Austin W. ; Flores-Huacuja, Marlen ; Snow, Meradeth ; Ramos-Madrigal, Jazmín ; Mendoza-Caamal, Elvia ; Baca, Paulina ; López-Escobar, Tomás A. ; Bolnick, Deborah A. ; Flores-Martínez, Silvia Esperanza ; Ortiz-Lopez, Rocio ; Kostic, Aleksandar David ; Villafan-Bernal, José Rafael ; Galaviz-Hernández, Carlos ; Centeno-Cruz, Federico ; García-Zapién, Alejandra Guadalupe ; Monge-Cázares, Tulia ; Lazalde-Ramos, Blanca Patricia ; Loeza-Becerra, Francisco ; Abrahantes-Pérez, María del Carmen ; Rangel-Villalobos, Héctor ; Sosa-Macías, Martha ; Rojas-Martínez, Augusto ; Martínez-Hernández, Angélica ; Orozco, Lorena. / Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico. In: Genes. 2022 ; Vol. 13, No. 12.

Bibtex

@article{fb6e64a2de1241759651cebccd315367,
title = "Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico",
abstract = "Few studies have addressed how selective pressures have shaped the genetic structure of the current Native American populations, and they have mostly limited their inferences to admixed Latin American populations. Here, we searched for local adaptation signals, based on integrated haplotype scores and population branch statistics, in 325 Mexican Indigenous individuals with at least 99% Native American ancestry from five previously defined geographical regions. Although each region exhibited its own local adaptation profile, only PPARG and AJAP1, both negative regulators of the Wnt/β catenin signaling pathway, showed significant adaptation signals in all the tested regions. Several signals were found, mainly in the genes related to the metabolic processes and immune response. A pathway enrichment analysis revealed the overrepresentation of selected genes related to several biological phenotypes/conditions, such as the immune response and metabolic pathways, in agreement with previous studies, suggesting that immunological and metabolic pressures are major drivers of human adaptation. Genes related to the gut microbiome measurements were overrepresented in all the regions, highlighting the importance of studying how humans have coevolved with the microbial communities that colonize them. Our results provide a further explanation of the human evolutionary history in response to environmental pressures in this region.",
keywords = "AJAP1, gut microbiome, local adaptation, Native American populations, PPARG",
author = "Humberto Garc{\'i}a-Ortiz and Francisco Barajas-Olmos and Cecilia Contreras-Cubas and Reynolds, {Austin W.} and Marlen Flores-Huacuja and Meradeth Snow and Jazm{\'i}n Ramos-Madrigal and Elvia Mendoza-Caamal and Paulina Baca and L{\'o}pez-Escobar, {Tom{\'a}s A.} and Bolnick, {Deborah A.} and Flores-Mart{\'i}nez, {Silvia Esperanza} and Rocio Ortiz-Lopez and Kostic, {Aleksandar David} and Villafan-Bernal, {Jos{\'e} Rafael} and Carlos Galaviz-Hern{\'a}ndez and Federico Centeno-Cruz and Garc{\'i}a-Zapi{\'e}n, {Alejandra Guadalupe} and Tulia Monge-C{\'a}zares and Lazalde-Ramos, {Blanca Patricia} and Francisco Loeza-Becerra and Abrahantes-P{\'e}rez, {Mar{\'i}a del Carmen} and H{\'e}ctor Rangel-Villalobos and Martha Sosa-Mac{\'i}as and Augusto Rojas-Mart{\'i}nez and Ang{\'e}lica Mart{\'i}nez-Hern{\'a}ndez and Lorena Orozco",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",
year = "2022",
doi = "10.3390/genes13122251",
language = "English",
volume = "13",
journal = "Genes",
issn = "2073-4425",
publisher = "M D P I AG",
number = "12",

}

RIS

TY - JOUR

T1 - Unraveling Signatures of Local Adaptation among Indigenous Groups from Mexico

AU - García-Ortiz, Humberto

AU - Barajas-Olmos, Francisco

AU - Contreras-Cubas, Cecilia

AU - Reynolds, Austin W.

AU - Flores-Huacuja, Marlen

AU - Snow, Meradeth

AU - Ramos-Madrigal, Jazmín

AU - Mendoza-Caamal, Elvia

AU - Baca, Paulina

AU - López-Escobar, Tomás A.

AU - Bolnick, Deborah A.

AU - Flores-Martínez, Silvia Esperanza

AU - Ortiz-Lopez, Rocio

AU - Kostic, Aleksandar David

AU - Villafan-Bernal, José Rafael

AU - Galaviz-Hernández, Carlos

AU - Centeno-Cruz, Federico

AU - García-Zapién, Alejandra Guadalupe

AU - Monge-Cázares, Tulia

AU - Lazalde-Ramos, Blanca Patricia

AU - Loeza-Becerra, Francisco

AU - Abrahantes-Pérez, María del Carmen

AU - Rangel-Villalobos, Héctor

AU - Sosa-Macías, Martha

AU - Rojas-Martínez, Augusto

AU - Martínez-Hernández, Angélica

AU - Orozco, Lorena

N1 - Publisher Copyright: © 2022 by the authors.

PY - 2022

Y1 - 2022

N2 - Few studies have addressed how selective pressures have shaped the genetic structure of the current Native American populations, and they have mostly limited their inferences to admixed Latin American populations. Here, we searched for local adaptation signals, based on integrated haplotype scores and population branch statistics, in 325 Mexican Indigenous individuals with at least 99% Native American ancestry from five previously defined geographical regions. Although each region exhibited its own local adaptation profile, only PPARG and AJAP1, both negative regulators of the Wnt/β catenin signaling pathway, showed significant adaptation signals in all the tested regions. Several signals were found, mainly in the genes related to the metabolic processes and immune response. A pathway enrichment analysis revealed the overrepresentation of selected genes related to several biological phenotypes/conditions, such as the immune response and metabolic pathways, in agreement with previous studies, suggesting that immunological and metabolic pressures are major drivers of human adaptation. Genes related to the gut microbiome measurements were overrepresented in all the regions, highlighting the importance of studying how humans have coevolved with the microbial communities that colonize them. Our results provide a further explanation of the human evolutionary history in response to environmental pressures in this region.

AB - Few studies have addressed how selective pressures have shaped the genetic structure of the current Native American populations, and they have mostly limited their inferences to admixed Latin American populations. Here, we searched for local adaptation signals, based on integrated haplotype scores and population branch statistics, in 325 Mexican Indigenous individuals with at least 99% Native American ancestry from five previously defined geographical regions. Although each region exhibited its own local adaptation profile, only PPARG and AJAP1, both negative regulators of the Wnt/β catenin signaling pathway, showed significant adaptation signals in all the tested regions. Several signals were found, mainly in the genes related to the metabolic processes and immune response. A pathway enrichment analysis revealed the overrepresentation of selected genes related to several biological phenotypes/conditions, such as the immune response and metabolic pathways, in agreement with previous studies, suggesting that immunological and metabolic pressures are major drivers of human adaptation. Genes related to the gut microbiome measurements were overrepresented in all the regions, highlighting the importance of studying how humans have coevolved with the microbial communities that colonize them. Our results provide a further explanation of the human evolutionary history in response to environmental pressures in this region.

KW - AJAP1

KW - gut microbiome

KW - local adaptation

KW - Native American populations

KW - PPARG

U2 - 10.3390/genes13122251

DO - 10.3390/genes13122251

M3 - Journal article

C2 - 36553518

AN - SCOPUS:85144535810

VL - 13

JO - Genes

JF - Genes

SN - 2073-4425

IS - 12

M1 - 2251

ER -

ID: 334010012