Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)

Research output: Contribution to journal › Journal article › Research › peer-review

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Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr). / Mochales-Riaño, Gabriel; Fontsere, Claudia; de Manuel, Marc; Talavera, Adrián; Burriel-Carranza, Bernat; Tejero-Cicuéndez, Héctor; AlGethami, Raed Hamoud M.; Shobrak, Mohammed; Marques-Bonet, Tomas; Carranza, Salvador.

In: iScience, Vol. 26, No. 9, 107481, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Mochales-Riaño, G, Fontsere, C, de Manuel, M, Talavera, A, Burriel-Carranza, B, Tejero-Cicuéndez, H, AlGethami, RHM, Shobrak, M, Marques-Bonet, T & Carranza, S 2023, 'Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)', iScience, vol. 26, no. 9, 107481. https://doi.org/10.1016/j.isci.2023.107481

APA

Mochales-Riaño, G., Fontsere, C., de Manuel, M., Talavera, A., Burriel-Carranza, B., Tejero-Cicuéndez, H., AlGethami, R. H. M., Shobrak, M., Marques-Bonet, T., & Carranza, S. (2023). Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr). iScience, 26(9), [107481]. https://doi.org/10.1016/j.isci.2023.107481

Vancouver

Mochales-Riaño G, Fontsere C, de Manuel M, Talavera A, Burriel-Carranza B, Tejero-Cicuéndez H et al. Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr). iScience. 2023;26(9). 107481. https://doi.org/10.1016/j.isci.2023.107481

Author

Mochales-Riaño, Gabriel ; Fontsere, Claudia ; de Manuel, Marc ; Talavera, Adrián ; Burriel-Carranza, Bernat ; Tejero-Cicuéndez, Héctor ; AlGethami, Raed Hamoud M. ; Shobrak, Mohammed ; Marques-Bonet, Tomas ; Carranza, Salvador. / Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr). In: iScience. 2023 ; Vol. 26, No. 9.

Bibtex

@article{7ab8b37da0624444920e8bfc6925e25f,

title = "Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)",

abstract = "In endangered species, low-genetic variation and inbreeding result from recent population declines. Genetic screenings in endangered populations help to assess their vulnerability to extinction and to create informed management actions toward their conservation efforts. The leopard, Panthera pardus, is a highly generalist predator with currently eight different subspecies. Yet, genomic data are still lacking for the Critically Endangered Arabian leopard (P. p. nimr). Here, we sequenced the whole genome of two Arabian leopards and assembled the most complete genomic dataset for leopards to date. Our phylogenomic analyses show that leopards are divided into two deeply divergent clades: the African and the Asian. Conservation genomic analyses indicate a prolonged population decline, which has led to an increase in inbreeding and runs of homozygosity, with consequent purging of deleterious mutations in both Arabian individuals. Our study represents the first attempt to genetically inform captive breeding programmes for this Critically Endangered subspecies.",

keywords = "Genomics, Zoology",

author = "Gabriel Mochales-Ria{\~n}o and Claudia Fontsere and {de Manuel}, Marc and Adri{\'a}n Talavera and Bernat Burriel-Carranza and H{\'e}ctor Tejero-Cicu{\'e}ndez and AlGethami, {Raed Hamoud M.} and Mohammed Shobrak and Tomas Marques-Bonet and Salvador Carranza",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s)",

year = "2023",

doi = "10.1016/j.isci.2023.107481",

language = "English",

volume = "26",

journal = "iScience",

issn = "2589-0042",

publisher = "Elsevier",

number = "9",

}

RIS

TY - JOUR

T1 - Genomics reveals introgression and purging of deleterious mutations in the Arabian leopard (Panthera pardus nimr)

AU - Mochales-Riaño, Gabriel

AU - Fontsere, Claudia

AU - de Manuel, Marc

AU - Talavera, Adrián

AU - Burriel-Carranza, Bernat

AU - Tejero-Cicuéndez, Héctor

AU - AlGethami, Raed Hamoud M.

AU - Shobrak, Mohammed

AU - Marques-Bonet, Tomas

AU - Carranza, Salvador

PY - 2023

Y1 - 2023

N2 - In endangered species, low-genetic variation and inbreeding result from recent population declines. Genetic screenings in endangered populations help to assess their vulnerability to extinction and to create informed management actions toward their conservation efforts. The leopard, Panthera pardus, is a highly generalist predator with currently eight different subspecies. Yet, genomic data are still lacking for the Critically Endangered Arabian leopard (P. p. nimr). Here, we sequenced the whole genome of two Arabian leopards and assembled the most complete genomic dataset for leopards to date. Our phylogenomic analyses show that leopards are divided into two deeply divergent clades: the African and the Asian. Conservation genomic analyses indicate a prolonged population decline, which has led to an increase in inbreeding and runs of homozygosity, with consequent purging of deleterious mutations in both Arabian individuals. Our study represents the first attempt to genetically inform captive breeding programmes for this Critically Endangered subspecies.

AB - In endangered species, low-genetic variation and inbreeding result from recent population declines. Genetic screenings in endangered populations help to assess their vulnerability to extinction and to create informed management actions toward their conservation efforts. The leopard, Panthera pardus, is a highly generalist predator with currently eight different subspecies. Yet, genomic data are still lacking for the Critically Endangered Arabian leopard (P. p. nimr). Here, we sequenced the whole genome of two Arabian leopards and assembled the most complete genomic dataset for leopards to date. Our phylogenomic analyses show that leopards are divided into two deeply divergent clades: the African and the Asian. Conservation genomic analyses indicate a prolonged population decline, which has led to an increase in inbreeding and runs of homozygosity, with consequent purging of deleterious mutations in both Arabian individuals. Our study represents the first attempt to genetically inform captive breeding programmes for this Critically Endangered subspecies.

KW - Genomics

KW - Zoology

U2 - 10.1016/j.isci.2023.107481

DO - 10.1016/j.isci.2023.107481

M3 - Journal article

C2 - 37601769

AN - SCOPUS:85167518115

VL - 26

JO - iScience

JF - iScience

SN - 2589-0042

IS - 9

M1 - 107481

ER -

ID: 362890467

Globe Institute