Macroevolution of complex retroviruses

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Macroevolution of complex retroviruses. / Katzourakis, Aris; Gifford, Robert J; Tristem, Michael; Gilbert, M Thomas P; Pybus, Oliver G.

In: Science, Vol. 325, No. 5947, 2009, p. 1512.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Katzourakis, A, Gifford, RJ, Tristem, M, Gilbert, MTP & Pybus, OG 2009, 'Macroevolution of complex retroviruses', Science, vol. 325, no. 5947, pp. 1512. https://doi.org/10.1126/science.1174149

APA

Katzourakis, A., Gifford, R. J., Tristem, M., Gilbert, M. T. P., & Pybus, O. G. (2009). Macroevolution of complex retroviruses. Science, 325(5947), 1512. https://doi.org/10.1126/science.1174149

Vancouver

Katzourakis A, Gifford RJ, Tristem M, Gilbert MTP, Pybus OG. Macroevolution of complex retroviruses. Science. 2009;325(5947):1512. https://doi.org/10.1126/science.1174149

Author

Katzourakis, Aris ; Gifford, Robert J ; Tristem, Michael ; Gilbert, M Thomas P ; Pybus, Oliver G. / Macroevolution of complex retroviruses. In: Science. 2009 ; Vol. 325, No. 5947. pp. 1512.

Bibtex

@article{8f586bd02b5711df8ed1000ea68e967b,
title = "Macroevolution of complex retroviruses",
abstract = "Retroviruses can leave a {"}fossil record{"} in their hosts' genomes in the form of endogenous retroviruses. Foamy viruses, complex retroviruses that infect mammals, have been notably absent from this record. We have found an endogenous foamy virus within the genomes of sloths and show that foamy viruses were infecting mammals more than 100 million years ago and codiverged with their hosts across an entire geological era. Our analysis highlights the role of evolutionary constraint in maintaining viral genome structure and indicates that accessory genes and mammalian mechanisms of innate immunity are the products of macroevolutionary conflict played out over a geological time scale.",
author = "Aris Katzourakis and Gifford, {Robert J} and Michael Tristem and Gilbert, {M Thomas P} and Pybus, {Oliver G}",
note = "Keywords: Amino Acid Sequence; Animals; Base Sequence; Endogenous Retroviruses; Evolution; Evolution, Molecular; Genome; Genome, Viral; Immunity, Innate; Molecular Sequence Data; Phylogeny; Retroviridae Infections; Sloths; Spumavirus; Time",
year = "2009",
doi = "10.1126/science.1174149",
language = "English",
volume = "325",
pages = "1512",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "5947",

}

RIS

TY - JOUR

T1 - Macroevolution of complex retroviruses

AU - Katzourakis, Aris

AU - Gifford, Robert J

AU - Tristem, Michael

AU - Gilbert, M Thomas P

AU - Pybus, Oliver G

N1 - Keywords: Amino Acid Sequence; Animals; Base Sequence; Endogenous Retroviruses; Evolution; Evolution, Molecular; Genome; Genome, Viral; Immunity, Innate; Molecular Sequence Data; Phylogeny; Retroviridae Infections; Sloths; Spumavirus; Time

PY - 2009

Y1 - 2009

N2 - Retroviruses can leave a "fossil record" in their hosts' genomes in the form of endogenous retroviruses. Foamy viruses, complex retroviruses that infect mammals, have been notably absent from this record. We have found an endogenous foamy virus within the genomes of sloths and show that foamy viruses were infecting mammals more than 100 million years ago and codiverged with their hosts across an entire geological era. Our analysis highlights the role of evolutionary constraint in maintaining viral genome structure and indicates that accessory genes and mammalian mechanisms of innate immunity are the products of macroevolutionary conflict played out over a geological time scale.

AB - Retroviruses can leave a "fossil record" in their hosts' genomes in the form of endogenous retroviruses. Foamy viruses, complex retroviruses that infect mammals, have been notably absent from this record. We have found an endogenous foamy virus within the genomes of sloths and show that foamy viruses were infecting mammals more than 100 million years ago and codiverged with their hosts across an entire geological era. Our analysis highlights the role of evolutionary constraint in maintaining viral genome structure and indicates that accessory genes and mammalian mechanisms of innate immunity are the products of macroevolutionary conflict played out over a geological time scale.

U2 - 10.1126/science.1174149

DO - 10.1126/science.1174149

M3 - Journal article

C2 - 19762636

VL - 325

SP - 1512

JO - Science

JF - Science

SN - 0036-8075

IS - 5947

ER -

ID: 18474296