Phenotypic Characterization and Comparative Genomic Analysis of Novel Salmonella Bacteriophages Isolated from a Tropical Rainforest
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Salmonella infections across the globe are becoming more challenging to control due to the emergence of multidrug-resistant (MDR) strains. Lytic phages may be suitable alternatives for treating these multidrug-resistant Salmonella infections. Most Salmonella phages to date were collected from human-impacted environments. To further explore the Salmonella phage space, and to potentially identify phages with novel characteristics, we characterized Salmonella-specific phages isolated from the Penang National Park, a conserved rainforest. Four phages with a broad lytic spectrum (kills >5 Salmonella serovars) were further characterized; they have isometric heads and cone-shaped tails, and genomes of similar to 39,900 bp, encoding 49 CDSs. As the genomes share a
Original language | English |
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Article number | 3678 |
Journal | International Journal of Molecular Sciences |
Volume | 24 |
Issue number | 4 |
Number of pages | 15 |
ISSN | 1661-6596 |
DOIs | |
Publication status | Published - 2023 |
- Salmonella, bacteriophages, tropical rainforest, comparative genomics, HOST-RANGE, RESISTANCE, ALIGNMENT
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